Have You or Someone You Know Had A Stroke?

We are seeking individuals who have had a recent stroke to participate in a research study of modified stem-cell therapy for the treatment of stroke.

This research study is called ACTIsSIMA (Allogenic Cell Therapy for Ischemic Stroke to Improve Motor Abilities).


You may be eligible to participate in this study if you:

  • Are between the ages of 18 and 75 years old
  • Have suffered a stroke within the last five years
  • Have ongoing weakness as a result of the stroke
  • Are able and willing to undergo CT and MRI brain scans as part of the study
  • Are able and willing to travel to study screening sites for final determination of eligibility, as well as other study-related procedures and follow-up visits

Note: Other inclusion and exclusion criteria apply.


This phase IIb clinical trial is designed to test the safety and efficacy of a modified stem-cell therapy that is administered directly to the injured brain through a neurosurgical procedure. Participants will have approximately seven follow-up visits for additional examinations, questionnaires, video recordings, and brain scans over the following 12 months. (See About the Study for additional details about ACTIsSIMA.)


We have developed an online eligibility questionnaire to help to see if you might be a candidate for this research study and future research studies for stroke. Individuals that complete this questionnaire may be contacted to learn more about this stem cell study, as well as future research studies for stroke.


The questionnaire includes detailed questions about your medical history and symptoms and should take about 30 minutes to complete. We will use this information to determine your initial eligibility and may contact you to obtain additional information and to tell you more about the study before you can enroll.


What Are Stem Cells?

Stem cells are cells that have the potential to develop into different types of cells within the body. The research study is investigating whether the adult bone-marrow-derived stem cells specifically developed for this study improve function after stroke.

What is a Clinical Trial?

A clinical trial is a research study designed to assess the safety or efficacy of a treatment or intervention. A Phase IIb clinical trial is specifically focused on the safety, tolerability, and dosing requirements of a treatment.

How do I find out if I might be eligible for this research study or future research studies?

Click here to take the Eligibility Questionnaire.